Scientists Think They've Found a New Cause of Type 2 Diabetes

Type 2 Diabetes Breakdown

Researchers from Case Western Reserve University uncover the reason behind insulin dysfunction in type 2 diabetes, affecting over half a billion people worldwide.

Insulin Functionality

Insulin, crucial for stable blood sugar, often loses its full effect in type 2 diabetes patients, leading to metabolic imbalances.

Discovery of SCAN Enzyme

Scientists identify a novel enzyme, SCAN (SNO-CoA-assisted nitrosylase), which facilitates the attachment of nitric oxide (NO) to target proteins like insulin receptors.

Role of Nitric Oxide

Nitric oxide, previously associated with various health conditions, is now linked to aspects of the body's metabolism, shedding light on its role in diabetes.

Enhanced SCAN Activity

In individuals with insulin resistance, SCAN activity is heightened, suggesting a potential mechanism for diabetes development.

Mouse Model Findings

In mouse models of diabetes, inhibiting SCAN enzyme activity prevented the manifestation of classic diabetes symptoms, hinting at its therapeutic potential.